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Handbook of Drug Screening, Vol. 114 <br />
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Type.................: Ebook<br />
Part Size............: 9,101,752 bytes<br />
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Posted by............: ~tqw~<br />
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A presentation of screening techniques, modern technologies, and high-capacity <br />
instrumentation for increased productivity in the development and discovery of <br />
new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It <br />
contains practical applications and examples of strategies in cell-based and <br />
cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and <br />
radioactive-based technologies.<br />
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Table of Contents<br />
<br />
Preface <br />
Contributors <br />
1 Moving Into the Third Millennium After a Century of Screening 1<br />
2 Basic Considerations in Designing High-Throughput Screening Assays 5<br />
3 Screening Platforms 31<br />
4 Homogeneous Assays for High-Throughput and Ultrahigh-Throughput <br />
Screening 69<br />
5 Microbe-Based Screening Systems 129<br />
6 Molecular Genetic Screen Design for Agricultural and Pharmaceutical <br />
Product Discovery 153<br />
7 Receptor Screens for Small Molecule Agonist and Antagonist Discovery <br />
189<br />
8 Functional Assay Screens 265<br />
9 Enzyme Screens 283<br />
10 Screening Strategies for Ion Channel Targets 313<br />
11 High-Throughput Screening Assays for Detection of Transcription 335<br />
12 Screening of Combinatorial Biology Libraries for Natural Products <br />
Discovery 357<br />
13 Higher-Throughput Screening Assays With Human Hepatocytes for <br />
Hepatotoxicity, Metabolic Stability, and Drug-Drug Interaction Potential <br />
383<br />
14 High-Throughput Screening for Metabolism-Based Drug-Drug Interactions <br />
403<br />
15 The ATCG of Drug Discovery 415<br />
16 Genomics/Functional Proteomics for Identification of New Targets <br />
433<br />
17 Bioinformatics: Identification of Novel Targets and Their <br />
Characterization 447<br />
18 The Evolution of Laboratory Automation 477<br />
19 Robotics and Automation 493<br />
20 Assay Miniaturization: Developing Technologies and Assay Formats 525<br />
21 Screening in the NanoWorld: Single-Molecule Spectroscopy and <br />
Miniaturized High-Throughput Screening 563<br />
Index 583<br />
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Product Details<br />
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* ISBN: 0824705629<br />
* ISBN-13: 9780824705626<br />
* Format: Hardcover, 520pp<br />
* Publisher: CRC Press<br />
* Pub. Date: January 2001<br />
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