Computational Methods for Mass Spectrometry Proteomics~tqw~ darksiderg

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  Computational Methods for Mass Spectrometry Proteomics~tqw~ darksiderg
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  *******************************************************************************<br /> Computational Methods for Mass Spectrometry Proteomics<br /> *******************************************************************************<br /> <br /> -------------------------------------------------------------------------------<br /> General Information<br /> -------------------------------------------------------------------------------<br /> Type.................: Ebook<br /> Part Size............: 4,653,208 bytes<br /> <br /> <br /> <br /> <br /> -------------------------------------------------------------------------------<br /> Post Information<br /> -------------------------------------------------------------------------------<br /> Posted by............: ~tqw~<br /> <br /> -------------------------------------------------------------------------------<br /> Release Notes<br /> -------------------------------------------------------------------------------<br /> Proteomics is the study of the subsets of proteins present in different parts of <br /> an organism and how they change with time and varying conditions. Mass <br /> spectrometry is the leading technology used in proteomics, and the field relies <br /> heavily on bioinformatics to process and analyze the acquired data. Since <br /> recent years have seen tremendous developments in instrumentation and <br /> proteomics-related bioinformatics, there is clearly a need for a solid <br /> introduction to the crossroads where proteomics and bioinformatics meet.<br /> <br /> Computational Methods for Mass Spectrometry Proteomics describes the different <br /> instruments and methodologies used in proteomics in a unified manner. The <br /> authors put an emphasis on the computational methods for the different phases of <br /> a proteomics analysis, but the underlying principles in protein chemistry and <br /> instrument technology are also described. The book is illustrated by a number of <br /> figures and examples, and contains exercises for the reader. Written in an <br /> accessible yet rigorous style, it is a valuable reference for both <br /> informaticians and biologists.<br /> <br /> Computational Methods for Mass Spectrometry Proteomics is suited for advanced <br /> undergraduate and graduate students of bioinformatics and molecular biology with <br /> an interest in proteomics. It also provides a good introduction and reference <br /> source for researchers new to proteomics, and for people who come into more <br /> peripheral contact with the field. <br /> <br /> Table Of Contents<br /> <br /> Preface ix<br /> Acknowledgements xi<br /> 1 Protein, proteome, and proteomics 1<br /> 2 Protein separation &ndash; 2D gel electrophoresis 31<br /> 3 Protein digestion 43<br /> 4 Peptide separation &ndash; HPLC 53<br /> 5 Fundamentals of mass spectrometry 67<br /> 6 Mass spectrometry &ndash; MALDI-TOF 81<br /> 7 Protein identification and characterization by MS 97<br /> 8 Tandem MS or MS/MS analysis 119<br /> 9 Fragmentation models 141<br /> 10 Identification and characterization by MS/MS 153<br /> 11 Spectral comparisons 159<br /> 12 Sequential comparison &ndash; de novo sequencing 179<br /> 13 Database searching for de novo sequences 193<br /> 14 Large-scale proteomics 211<br /> 15 Quantitative MS-based proteomics 229<br /> 16 Peptides to proteins 243<br /> 17 Top-down proteomics 249<br /> 18 Standards 255<br /> Bibliography 265<br /> Index 277<br /> <br /> Product Details<br /> <br /> * ISBN: 0470512970<br /> * ISBN-13: 9780470512975<br /> * Format: Hardcover, 296pp<br /> * Publisher: Wiley, John &amp; Sons, Incorporated<br /> * Pub. Date: February 2008<br /> <br /> -------------------------------------------------------------------------------<br /> Install Notes<br /> -------------------------------------------------------------------------------<br /> PDF Reader
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